cross-species transmission

Dynamics of viral index infections in novel hosts

Why most cross-species transmissions fail to establish ongoing transmission in the newly infected species remains poorly understood. Examining cross-species inoculations involving rabies, we show that mismatches in virulence which are predictable from host and viral factors make sustained transmission in the novel host less likely. These mechanistic insights help to explain and predict host shift events and highlight meta-analyses of existing experimental inoculation data as a powerful and generalisable approach for understanding the dynamics of index infections in novel species.

The role of viral evolution in rabies host shifts and emergence

Despite its ability to infect all mammals, Rabies virus persists in numerous species-specific cycles that rarely sustain transmission in alternative species. The determinants of these species-associations and the adaptive significance of genetic …